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Born in Detroit, Michigan and raised in Queens, New York, Missy’s first real memory of singing is at age six. Her mother entered Missy in a child talent contest and everyday she practiced with her after school. It was her favorite thing to do. For some reason the contest was cancelled and her afternoon practice sessions stopped, but Missy was hooked from then on. “Singing would always be my friend and I would turn to it whenever I needed to express something I couldn’t find the words to say,” says Missy.

Her parents had an extensive music collection that included lots of soul, R&B, blues, jazz, and gospel. Her favorite songs were always the ones that told a story. It wasn’t always the most popular song on the album, but she would play them over and over and over. She listened to Gladys Knight, Aretha Franklin, James Brown, The Staple Singers, Teddy Pendergrass and a host of others. And like many before her, Missy mimicked other singers until she found her own voice. Later she would discover Dinah Washington, Sarah Vaughn, and Billie Holiday and that eventually lead her to O.V. Wright, Bobby Bland, Little Milton, James Carr, Ray Charles, Ann Peebles, and Irma Thomas.

Although singing was her love, she had her first stab at the music business while in her teens with the rap single, “Be For Real” under the moniker, Denyce "Flip" Isaac. Although the record’s success was small, it still led to her being the opening act for Cissy Houston in a string of club dates. It wasn’t long before Missy turned back to singing, honing her skills fronting local bands as well as doing studio sessions as a background vocalist.

Moving to San Diego, California, she met local blues man, Earl Thomas in the late 90’s. It was then that she became one of the original Juke Joint Jezebelles, a gospel, blues, and soul quartet, who provided backup vocals for Earl’s stage show. She played and toured with Earl for several years hitting festivals and venues in the U.S. and Europe. Earl Thomas and the Jezebelles shared the stage with Ray Charles, B.B. King, Robert Cray, John Hammond, Keb’ Mo’, Kenny Neal, and The Meters.