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Friedman is a largely self-taught guitarist, known for his improvisation and for fusing an Eastern musical feel with Western musical styles, such as neo-classical, thrash metal and later on into progressive rock.

Prior to joining Megadeth, he formed and played lead guitar in several other bands, including Deuce, Hawaii, and notably Cacophony. Cacophony featured neoclassical metal elements and synchronized twin guitar harmonies and counterpoints shared with guitarist Jason Becker on their two albums, Go Off! and Speed Metal Symphony.

Currently living in Shinjuku, Tokyo, Japan, he travels the world giving clinics, performances and master classes in dozens of countries in Asia, Europe, North and South America. He has become a major force in the Japanese music scene, playing lead guitar in the bands of some of the country's most famous performers. He also appears on Japanese television and as a columnist for a major Japanese music magazine and a national daily newspaper.

Friedman speaks fluent Japanese. He became a regular member of the cast of TXN's musical TV program hebimeta-san (ヘビメタさん) (anglicized as "Mr. Heavy-Metal") with Japanese idol Yoko Kumada before the show came to an end in 2005. He had his own heavy metal TV program called Rock Fujiyama alongside Shelly, Kenny Guy, Rock Ninja Yorimasa and ex-Scanch member, Rolly Teranishi from April 2006 until March 2007. In November~December 2005 he went touring with Japanese singer Ami Suzuki inside her "Suzuki Ami Around the World" Live House Tour, which took place in cities like Tokyo, Osaka and Nagoya.

Marty has played the guitar in support for Japanese musicians such as Nanase Aikawa, miyavi, and former Pierrot vocalist Kirito.

More recently, Marty has been featured in Jukebox, a television program in which Marty and two Japanese people translate the lyrics of various English songs into understandable Japanese.